Gout is a common inflammatory arthritis caused by uric acid crystals forming in a joint, producing sudden attacks of severe pain, swelling and redness — often first in the big toe. Attacks are treatable, and future attacks are largely preventable.
Gout is a form of inflammatory arthritis caused by uric acid crystals depositing in a joint, triggering sudden attacks of intense pain, swelling, heat and redness — most often first in the big toe, but it can affect many joints. It develops when uric acid in the blood is persistently high. Attacks settle over days, but without treatment they tend to recur, become more frequent, and can eventually cause permanent joint damage and lumps called tophi.
An acute attack can closely resemble a joint infection, so a hot, swollen joint — particularly with fever or feeling unwell — needs prompt assessment. Diagnosis uses a uric acid blood test (interpreted carefully, as it can be normal during a flare) and, where needed, examination of joint fluid for crystals.
Management has two parts: settling the acute attack (an NSAID, low-dose colchicine or a corticosteroid), and — for recurrent gout, tophi or joint damage — long-term urate-lowering therapy using a treat-to-target approach, with allopurinol first-line (febuxostat or probenecid as alternatives). The Australian serum urate target is below 0.36 mmol/L, or below 0.30 mmol/L with tophi. Lifestyle measures help, and because gout is closely linked with cardiovascular and metabolic disease, it is also an opportunity to review blood pressure, weight, diabetes and medications. This is usually managed in general practice.